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GPCR-Symposium 2016

1st Symposium on Functional Autoantibodies Targeting G-Protein-Coupled Receptors

Lübeck, October 07-09, 2016


Greeting from the symposium chair
 

Dear Sir or Madam, Dear colleagues,

It is a great pleasure to announce the first symposium on functional autoantibodies targeting G-protein-coupled receptors (GPCRs) in Lübeck. GPCRs are involved in a variety of physiological and pathophysiological processes. So far, much effort has been made on anti-GPCR drug discovery with a focus on the development of small molecules and monoclonal antibodies for the treatment of cancer, infection, metabolic disorders or inflammatory diseases. Recently, functional autoantibodies against GPCRs were identified in various diseases associated with pathogenesis, uncovering a potential new field of therapeutic intervention. Thus, the aim of this symposium is to combine the current knowledge about the role of GPCRs in different pathologies, their mode of action and state-of-the-art research techniques to identify common fundamental pathways that can be transferred to other disease entities with similar manifestations.

I cordially invite you to participate in this inspiring symposium with outstanding speakers from the field of GPCR research and constructive discussions as well as poster sessions. I look forward to welcome you to the beautiful Hanseatic City of Lübeck and encourage you and your colleagues to contribute to this exciting meeting.

Prof. Dr. Gabriela Riemekasten 
- Director, Department of Rheumatology -

Sponsors of GPCR 2016

Symposium Chair

Prof. Dr. Gabriela Riemekasten
Department of Rheumatology
University of Lübeck

Flyer

Scientific Program

Friday, October 7, 2016

3:00pm 

Registration

5:00pm

Welcome from the University President: Hendrik Lehnert
Welcome the chair of the Symposium: Gabriela Riemekasten

5:20pm

Opening Lecture: Autoantibodies against GPCR – a new principle to understand diseases

6:00pmWelcome Reception
Saturday, October 8, 2016

9:00am

GPCRs and their modulation in neurological diseases
Madlen Löbel: Immunoadsorption to remove ß adrenergic and M acetylcholine receptor antibodies in Chronic Fatigue Syndrome
Lasse Melvaer Giil: Antibodies to signaling molecules and receptors in Alzheimer’s disease - Immune-related cognitive dysfunction and mortality.
Oral presentations from selected abstracts

10:00am

Coffee break

10:30am

GPCRs and their modulation in cardiovascular diseases
Florian Herse: AT1-Autoantibodies in hypertensive disease of pregnancy
Fritz Boege: Agonistic autoantibodies against 1-adrenergic receptors in dilated cardiomyopathy
Annekathrin Haberland: BC 007, an aptamer for the neutralization of functional autoantibodies directed against GPCR that are identified by a functional test
Oral presentations from selected abstracts

12:00pm

Lunch

1:15pm

Poster Session

2:00pm

GPCRs and their modulation in hemato-oncological diseases
Thomas Luft: Role of autoantibodies directed against GPCRs in GVHD after allogenic SCT
Frank Gieseler: PAR2, a G-protein coupled receptor protein (GPR11): Possible relevance of aberrant expression by tumor cells
Oral presentations from selected abstracts

3:00pm

Coffee Break

3:30pm

GPCRs and their modulation in rheumatic diseases
Gabriela Riemekasten: Antibodies against GPCR in systemic sclerosis
Xinhua Yu: Autoantibodies against peptides of GPCRs in primary Sjögren’s syndrome
Otávio Cabral-Marques: Physiological IgG autoantibodies regulate a network of G protein coupled receptors and growth factors
Oral presentations from selected abstracts

6:00pm

Social event

8:00pm

Dinner at the “Kartoffelkeller” in the historical center of Lübeck

Sunday, October 9, 2016

9:00am

GPCR antibodies and their signaling
Duska Dragun: Personalized medicine for transplant recipients according to anti-GPCR antibody status
Aurélie Philippe: New approaches to study functional selectivity in GPCR signaling
Christian Sadik: SSc- IgG effects are mediated through distinct pathways in THP-1 cells
Oral presentations from selected abstracts

10:30am

Coffee break

11:00pm

Therapeutic approaches regarding GPCR modulation
Roland Jahns: Novel therapeutic approaches in cardiac autoimmunity:
Blocking peptides against beta1-adrenoceptor autoantibodies
Manuela Camino: Autoantibodies against beta 1 adrenergic receptors in dilated cardiomiopathy in children - treatment with immunoadsorption
Oral presentations from selected abstracts

12:00pm

Panel discussion and closing remarks: Gabriela Riemekasten Future directions and therapeutic approaches

12:45pm

Lunch

Sponsors of the 1st RAB-Symposium

Disclosure of cooperation

Disclosure of payments made during the 1st RAB-Symposium
In accordance with transparency obligations, we transparently present the services and the extent of support provided by companies to participants both in announcing and holding the congress.

Institution

SponsoringService
CellTrend GmbH   3.000 €Industrial exhibition, Marketing
Janssen-Cilag GmbH    2.000 €Industrial exhibition, Marketing
Bristol-Myers Squibb GmbH & Co. KGaA   2.000 €Industrial exhibition, Marketing
Lilly Deutschland GmbH   2.000 €Industrial exhibition, Marketing
Miltenyi Biotec GmbH   1.000 €Industrial exhibition, Marketing
Novartis Pharma GmbH   1.000 €Industrial exhibition, Marketing
Actelion Pharmaceuticals Deutschland GmbH   1.000 €Industrial exhibition, Marketing
AbbVie Deutschland GmbH & Co. KG      700 €Industrial exhibition, Marketing
Pfizer Deutschland GmbH      500 €Marketing
medac GmbH      500 €Marketing
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